Researchers have discovered CB3 Cannabinoid Receptor

Researchers have discovered a new cannabinoid receptor, CB3, one that could open a new door of healing possibilities.

This isn’t anything like anyone has seen before: This new research suggests that cannabis may influence the human body in new and extraordinary ways.

Before we go into more detail, let’s go over some brief history:

After the U.S. government belatedly allowed scientists to move forward in research of the possible medical uses of cannabis, whole dimensions of human biochemistry which formerly existed in the shadows suddenly shifted into the light. In the 1990s, the discovery of the endocannabinoid system came about—a vitally essential component of the central nervous system that plays a role in everything; from cognitive processes and pain sensation to appetite regulation and physical activity.

It was the discovery of the decade. In a phenomenally narrow window, science has gained a deeper comprehension of how the mammalian body manages and regulates itself.

Because the endocannabinoid system grasps various domains of the human experience, it is a gargantuanly productive ground for research.

The biggest focus in the endocannabinoid system is two cannabinoid receptors most commonly referred to as CB1 and CB2. These molecules are where the magic happens. Like all biochemical receptors, CB1 and CB2 are protein molecules that receive chemical signals from outside the cell. Think of them like the area on your television that you point the remote control at. They sit dormant until they receive a signal, then they spring into action.

What is the CB3 Cannabinoid Receptor?
For years, CB1 and CB2 stood by themselves. But now, scientists think they’ve pinpointed a new cannabinoid receptor, one that could change everything we know about the endocannabinoid system.

The molecule in question goes by the name GPR55 but may soon be known as CB3. The molecule itself was first discovered in 1999 in various parts of the brain—the hippocampus, cerebellum, thalamus, etc. But newer research has discovered that it also hides out in more remote parts of the body, such as the spleen, GI tract and adrenal glands.

If this molecule is truly a cannabinoid receptor, that means the current understanding of the endocannabinoid system is immensely fragmentary. This molecule is distinctly different from CB1 and CB2, which share a lot of similar characteristics. In comparison, GPR55 shares less than 15% of its amino acid identity with either.

The potential here is extremely huge. It could explain why CBD oil has such a diverse range of health benefits, a variety of which are proven through trials but poorly understood from a scientific perspective. If researchers could unlock the mechanism by which medical cannabis operates, it could lead us toward developing new and more effective therapies for all kinds of diseases. Woo!!

But it’s not just that. The new receptor is also found in cancer cells.

The presence of GPR55 in cancer cells might sound scary, but it’s worth getting excited about.

While the exact functions and pharmacology of GPR55 are far from understood, if research discovers what it’s doing in cancer cells, we’ll know more about cancer itself: How it emerges, how it spreads and how to stop it.

And if turns out that we can influence cancer by manipulating a cannabinoid receptor or the body’s endocannabinoid system, we’ll have more weapons in our arsenal of anti-tumor remedies. That’s huge!!!

One of the noteworthy theories circulating about the properties of CB3 is that the body may have the ability to transform one kind of cannabinoid to another. If that’s true, and cancer cells use CB3 for some corrupt purpose, it could be possible to engineer a change-resistant form of cannabinoid that slows the progression of tumors.

Of course, that’s entirely theoretical—and a long way off. However, the possibilities are worth the hype! CB3 could present the next breakthrough in treating human suffering. It’s another level up in hope of reversing diseases previously believed uncurable.

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CBD Massages Will Bring You To Your Maximum Relaxation Level

Move over, regular massages. Many spas are now starting to offer CBD massages, following the recent boom in popularity of the cannabis compound, and yes, they will bring you to your maximum level of chill.

CBD, aka cannabidiol, is a compound derived from the hemp plant that you’ve probably seen everywhere in the last few months. CBD has become a super popular addition to many common products — including your fave beauty essentials like lip balm or mascara, brownies (naturally), and even vape pens. Unlike THC, another active compound in cannabis, CBD is non-psychoactive, and studies have concluded that it may have a range of health benefits, from helping seizure patients to general de-stressing. You can experience the benefits of CBD orally, through oils, pills, or tinctures, or apply it topically — which brings us back to the whole massage situation.

Cyndi Ramirez Fulton, the founder of Chillhouse, a self-care oasis that offers manicures, massages, and a wellness café in New York City, tells Bustle that adding a CBD massage balm option to their services was a “no brainer.” She explains, “[I’m] not always one to always jump on wellness trends for the hell of it. [But] CBD products are obviously thriving right now.” At Chillhouse, you can add CBD to your service as a $15 add-on.

So, what are the benefits to CBD massage? Obviously, many people who ingest CBD-infused edibles find it relaxes them and improves their mood, but a CBD massage will do the same thing — without the high, or risk of potentially triggering mental health issues like anxiety. In fact, many people who’ve received a CBD massage claim the practice is a perfect way to destress and relieve anxiety: As Anna Gragert, writing for Hello Giggles, explained, the whole experience made her feel “present in the moment, and accepting of the fact that this was my time to shed pounds of stress.”

Moreover, when applied topically, CBD can be extremely beneficial for people experiencing chronic physical pain. “CBD cream has natural anti-inflammatory effects that can more effectively soothe sore muscles and joints. It encourages the body to speed up the healing process, and is beneficial in relieving anxiety, as well as gastric distress,” explains Ramirez-Fulton, adding that the CBD balm Chillhouse uses “also has arnica and lidocaine for further anti-inflammatory benefits.”

Considering inflammation is believed to play a crucial role in chronic pain and many common health issues, anything that reduces inflammation is a win in my book. Not to mention, studies have also found that CBD has analgesic — aka, pain relieving qualities, making it a ultra-soothing oil to use during a massage. Further, research has shown that CBD may pack benefits for your skin and control acne, so you don’t have to worry about the oil making your back break out.

You don’t just have to be in New York City to get a CBD-infused massage, either, The Now in Los Angeles, California, also offers a CBD add-on to any massage for $10, and Renu Day Spa in Illinois offers a 60 or 90 minute CBD oil infused massage for $90 or $125, respectively. You can also Google CBD massages to find one in your area, if you live in a state where CBD is legal.

Ramirez-Fulton says CBD massages are not just a trend, but are “here to stay.” Though CBD is not legal in every U.S. state (yet!), hopefully more people will recognize the benefits of using this oil to manage pain and stress. So, if you’re lucky enough to live in a CBD-friendly city, you can definitely give this growing practice a try. A CBD massage may be the key to leaving your anxiety behind, if only for an hour, and allowing yourself to experience ultimate relaxation.

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A Group Of Medical Cannabis Companies In Texas Are Subsidising The High Cost Of CBD For Patients.

A Group Of Medical Cannabis Companies In Texas Are Subsidising The High Cost Of CBD For Patients

Epilepsy patients in Texas are having great success with CBD for treating seizures, but there’s a catch. The cost of the drugs are high and often, not covered by insurance, so local businesses are stepping up to create a compassionate patient assistance program.

Epilepsy patients in Texas like Jordan Herrera used to have to take  dangerous anti-convolution medications. But now, she has access to cannabis derived medications such as CBD, a substance Jordan’s mother, Janet, says has worked wonders for her.

“It’s still trial and error,” Janet told powr. “But the CBD-oil, I can tell you, hands down, has done really good things for her.”

However, there is a downside. Jordan’s new medications are not covered by insurance, and this has caused some financial stress for Janet.

“The coast and expense for me has been exponential.”

This is where two Texas-based medical marijuana companiesCompassionate Cultivation and Nox Medicalcome in. They’ve each decided to donate $5000 to The Epilepsy Foundation of Central and South Texas to create a compassionate use patient assistance program. A new program which Compassionate Cultivation CEO, Morris Denton says should help some who can’t afford the medical marijuana get the medication they need.

“And I know that there would be a lot of people out there that wouldn’t be able to afford this medicine and really, really need it and can really, really benefit from it,” says Denton.

For Janet, this is big step towards helping patients get proper treatment.

“This, right here, is life saving,” she said. “And potentially more effective than any anti-convolution medication on the market.”

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Increasing numbers of young Americans are choosing marijuana over cigarettes or alcohol as their first drug of choice, according to new research published in the journal Prevention Science.  

Researchers from the National Institute of Child Health and Human Development (NICHD) examined nationally representative survey data from more than 275,000 people aged between 12 and 21. The study is based on the National Survey on Drug Use and Health, which was conducted between 2004 and 2014 and involved questions related to the use of marijuana, tobacco, alcohol as well as other illegal drugs.

The researchers found that around 8 percent of respondents in 2014 reported that marijuana was the first drug they ever used—almost double the figure of 4.8 percent reported in 2004. This rise could be related to a declining rate of young smokers (21 percent in 2004 to 9 percent in 2014) or the larger number of young people abstaining from substance use altogether (36 percent to 46 percent in 2014), according to the researchers.

The trend is particularly noticeable in specific ethnic groups. Researchers found that  young people who used marijuana as their first drug were more likely to be male and come from black, Native American, Hispanic or multiracial backgrounds.

“Our findings suggest important targets for public health intervention and prevention of marijuana use, especially among American Indian/Alaska Native and Black youth, who are less likely to have access to treatment or successful treatment outcomes,” Brian Fairman, a postdoctoral researcher at the NICHD, said in a statement.
Fairman said that young people who started off on marijuana before alcohol or tobacco were more likely to become heavy users and have cannabis-related problems later in life. In light of this, he recommended that drug prevention strategies be targeted at different groups depending on their specific risk of using marijuana, alcohol or tobacco first.

“To the degree these trends continue, and greater numbers of youth start with marijuana as their first drug, there may be an increasing need for public interventions and treatment services for marijuana-related problems,” Fairman said.

The rise in young people abstaining from substance use in the new report resonates with previous research into drug use among this group. One study, for example, found that substance use disorders for adolescents between the age of 12 and 17 dropped a whopping 49 percent between the years 2003 and 2014.

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